The leishmaniases are a group of diseases caused by protozoan parasites from more than 20 Leishmania species. These parasites are transmitted to humans by the bite of an infected female phlebotomine sandfly, a tiny – 2–3 mm long – insect vector.

There are three main forms of the disease: cutaneous leishmaniasis (CL), visceral leishmaniasis (VL), also known as kala-azar, and mucocutaneous leishmaniasis (MCL). CL is the most common form, VL is the most severe form and MCL is the most disabling form of the disease.

Symptoms may occur within 1 year but can also take as long as 20 years or even more to occur.

Clinical signs are easy to observe. Skin lesion has usually a different pigmentation than the surrounding normal skin (less pigmented, reddish or copper-coloured) and may have various aspects (flat, raised or nodules). Skin lesion can be single or multiple and may show a loss of sensation in the skin.

Skin smears are also used to diagnose leprosy.

People infected with filariasis who have microfilaraemia or a positive antigen test should receive antifilarial drug treatment to eliminate microfilariae. Unfortunately, the medicines available have limited effect on adult worms. Treatment also involves the management of morbidity and disability prevention (MMDP) that includes simple hygiene measures, such as basic skin care and exercise, to prevent acute attacks and progression of lymphoedema to elephantiasis. For management of hydrocoele, surgery may be appropriate.

There is as yet no proven treatment available for Marburg virus disease. However, a range of potential treatments including blood products, immune therapies and drug therapies are currently being evaluated. Supportive care – rehydration with oral or intravenous fluids – and treatment of specific symptoms improves survival. 

Illness caused by Marburg virus begins abruptly, with high fever, severe headache and severe malaise. Muscle aches and pains are a common feature. Severe watery diarrhoea, abdominal pain and cramping, nausea and vomiting can begin on the third day. Diarrhoea can persist for a week. The appearance of patients at this phase has been described as showing “ghost-like” drawn features, deep-set eyes, expressionless faces and extreme lethargy. A non-itchy rash has been noted between 2 and 7 days after the onset of symptoms. 
 

Universal health coverage can only be achieved when there is affordable access to safe, effective and quality medicines and health products. WHO works with partners and Member States to strengthen regulation, including post-marketing surveillance, and to eliminate substandard and falsified medicines. It also develops international norms and standards so that countries worldwide can regulate health products and technologies consistently.

Mental health conditions are increasing worldwide. Mainly because of demographic changes, there has been a 13% rise in mental health conditions and substance use disorders in the last decade (to 2017). Mental health conditions now cause 1 in 5 years lived with disability. Around 20% of the world’s children and adolescents have a mental health condition, with suicide the second leading cause of death among 15-29-year-olds. Approximately one in five people in post-conflict settings have a mental health condition.

WHO works with Member States and partners to prevent micronutrient deficiencies though a number of programmes and following the WHO 2016–2025 nutrition strategy. These programmes include iron and folic acid supplementation, high dose vitamin A supplementation, the promotion of breastfeeding, fortification of foods with micronutrients, and healthy, diverse diets containing foods naturally rich in vitamin and minerals.

Monkeypox presents with fever, an extensive characteristic rash and usually swollen lymph nodes. It is important to distinguish monkeypox from other illnesses such as chickenpox, measles, bacterial skin infections, scabies, syphilis and medication-associated allergies.  

In 2014, 194 Member States of the Sixty-seventh World Health Assembly endorsed the action plan (Resolution WHA 67.10). Led by UNICEF and the World Health Organization, Every Newborn Action Plan (ENAP) was guided by the advice of experts and partners and by multistakeholder consultations and a web-based consultation with over 300 comments from stakeholders. The WHO Director-General has been requested to monitor progress towards the achievement of the global goal and targets, reporting periodically to the World Health Assembly until 2030.

Nipah virus infection is a zoonotic illness that is transmitted to people from animals, and can also be transmitted through contaminated food or directly from person-to-person. In infected people, it causes a range of illnesses from asymptomatic (subclinical) infection to acute respiratory illness and fatal encephalitis. The virus can also cause severe disease in animals such as pigs, resulting in significant economic losses for farmers.

There are currently no drugs or vaccines that specifically target Nipah virus infection. WHO has identified Nipah as a priority disease for the WHO Research and Development Blueprint.

Intensive supportive care is recommended to treat severe respiratory and neurologic complications

Nursing encompasses autonomous and collaborative care of individuals of all ages, families, groups and communities, sick or well and in all settings. It includes the promotion of health, the prevention of illness, and the care of ill, disabled and dying people. Nurses play a critical role in health care and are often the unsung heroes in health care facilities and emergency response.

WHO recognizes the vital role that nurses play in primary health care delivery worldwide – including research, disease prevention, treating the injured, palliative care and more – which is represented through several World Health Assembly resolutions. These documents demonstrate the importance WHO Member States attach to nursing and midwifery services as a means of achieving better health for all communities.

Nutrition is a critical part of health and development. Better nutrition is related to improved infant, child and maternal health, stronger immune systems, safer pregnancy and childbirth, lower risk of non-communicable diseases (such as diabetes and cardiovascular disease), and longevity.

Healthy children learn better. People with adequate nutrition are more productive and can create opportunities to gradually break the cycles of poverty and hunger.