Automated Computer Assistant for Kidney Transplant Rejection Diagnostics: Interview with Study Authors

A recent study in Nature Medicine, entitled “An automated histological classification system for precision diagnostics of kidney allografts,” has showcased the efforts of a group of researchers who have developed an automated system that can diagnose kidney transplant rejection.

A variety of disparate factors can affect the chances that a transplant will be rejected. At present, clinicians have to manually consider these complex data when making decisions about transplant patients, which can lead to a high level of misdiagnosis and patient morbidity.

Maternal health

Maternal health refers to the health of women during pregnancy, childbirth and the postnatal period. 

Each stage should be a positive experience, ensuring women and their babies reach their full potential for health and well-being. 

Although important progress has been made in the last two decades, about 295 000 women died during and following pregnancy and childbirth in 2017. This number is unacceptably high.

Maternal health WHO Response

Improving maternal health is one of WHO’s key priorities, grounded in a human rights approach and linked to efforts on universal health coverage.  

WHO advocates for health planning where women’s values and preferences are at the centre of their own care. Meaningful engagement and empowerment of women, families, communities, and providers is essential for quality improvement initiatives.

Maternal health Impact

About 140 million births take place every year and the proportion attended by skilled health personnel has increased: from 58% in 1990 to 81% in 2019. This is mostly due to larger numbers of births taking place at a health facility. 

Deaths from complications during pregnancy, childbirth, and the postnatal period have declined by 38% in the last two decades, but at an average reduction of just under 3% per year, this pace of progress is far too slow. 

It also hides vast inequalities within and across countries. 

Measles

Measles is a highly contagious viral disease. It remains an important cause of death among young children globally, despite the availability of a safe and effective vaccine.

While vaccination has drastically reduced global measles deaths — a 73% drop between 2000-2018 worldwide — measles is still common in many developing countries, particularly in parts of Africa and Asia. More than 140,000 people died from measles in 2018. The overwhelming majority (more than 95%) of measles deaths occur in countries with low per capita incomes and weak health infrastructures.

Measles Symptoms

Measles is transmitted via droplets from the nose, mouth or throat of infected persons. Initial symptoms, which usually appear 10–12 days after infection, include high fever, a runny nose, bloodshot eyes, and tiny white spots on the inside of the mouth. Several days later, a rash develops, starting on the face and upper neck and gradually spreading downwards.

Measles Treatmen

Routine measles vaccination for children, combined with mass immunization campaigns in countries with low routine coverage, are key public health strategies to reduce global measles deaths.

Mental health WHO Response

WHO works with Member States and partners to improve the mental health of individuals and society at large. This includes the promotion of mental well-being, the prevention of mental disorders, and efforts to increase access to quality mental health care that respects people’s human rights. In 2019, WHO launched the WHO Special Initiative for Mental Health (2019-2023): Universal Health Coverage for Mental Health to ensure access to quality and affordable care for mental health conditions in 12 priority countries to 100 million more people.

Micronutrients

Micronutrients are vitamins and minerals needed by the body in very small amounts. However, their impact on a body’s health are critical, and deficiency in any of them can cause severe and even life-threatening conditions. They perform a range of functions, including enabling the body to produce enzymes, hormones and other substances needed for normal growth and development. Deficiencies in iron, vitamin A and iodine are the most common around the world, particularly in children and pregnant women.

Middle East respiratory syndrome coronavirus (MERS-CoV)

Middle East respiratory syndrome coronavirus (MERS-CoV) is a virus transferred to humans from infected dromedary camels. It is a zoonotic virus, meaning it is transmitted between animals and people, and it is contractable through direct or indirect contact with infected animals. MERS-CoV has been identified in dromedaries in several countries in the Middle East, Africa and South Asia. In total, 27 countries have reported cases since 2012, leading to 858 known deaths due to the infection and related complications.

Monkeypox Treatment

Treatment of monkeypox patients is supportive dependent on the symptoms. Various compounds that may be effective against monkeypox virus infection are being developed and tested.  

Prevention and control of human monkeypox rely on raising awareness in communities and educating health workers to prevent infection and stop transmission. 

Most human monkeypox infections result from a primary animal-to-human transmission. Unprotected contact with sick or dead animals should be avoided, and all foods containing animal meat or parts need to be properly cooked before eating. 

Mycetoma, chromoblastomycosis and other deep mycoses

Mycetoma is a chronic, progressively destructive morbid inflammatory disease usually of the foot but any part of the body can be affected. Infection is most probably acquired by traumatic inoculation of certain fungi or ‎bacteria into the subcutaneous tissue. Mycetoma was described in the modern literature in 1694 but was first reported in the mid-19th century in the Indian town of Madura, and hence was initially called Madura foot.