There is currently no licensed vaccine for Lassa fever, but several potential vaccines are in development. Despite not being licensed as a treatment for Lassa fever the antiviral drug ribavirin has been used in several countries as a therapeutic agent. However, there is still a need for a safe treatment with proven efficacy, and a range of potential treatments including immune therapies and drug therapies are currently being evaluated. No evidence supports the role of ribavirin as a treatment for Lassa fever.
Prevention of Lassa fever relies on promoting good “community hygiene” to discourage rodents from entering homes. Effective measures include storing foodstuffs in rodent-proof containers, disposing of garbage far from the home, maintaining clean households and keeping cats. Because Mastomys rats are so abundant in endemic areas, it is not possible to eliminate them from the environment. Family members should always be careful to avoid contact with blood and body fluids while caring for sick persons.
Lassa fever is known to be endemic. Health-care workers seeing a patient suspected to have Lassa fever should immediately contact local and national experts for advice and to arrange for laboratory testing. Health care staff should apply standard infection prevention and control precautions
Lassa fever
Lassa fever is an acute viral haemorrhagic illness caused by Lassa virus, a member of the arenavirus family of viruses.
Humans usually become infected with Lassa virus through exposure to food or household items contaminated with urine or faeces of infected Mastomys rats. The disease is endemic in the rodent population in parts of West Africa.
Lassa fever is known to be endemic in Benin, Ghana, Guinea, Liberia, Mali, Sierra Leone, Togo and Nigeria, but probably exists in other West African countries as well.
Person-to-person infections and laboratory transmission can also occur, particularly in health care settings in the absence of adequate infection prevention and control measures.
Diagnosis and prompt treatment are essential. The overall case-fatality rate is 1%. Among patients who are hospitalized with severe clinical presentation of Lassa fever, case-fatality is estimated at around 15%. Early supportive care with rehydration and symptomatic treatment improves survival.
About 80% of people who become infected with Lassa virus have no symptoms. 1 in 5 infections result in severe disease, where the virus affects several organs such as the liver, spleen and kidneys.
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