M.B.B.S. EXAMINATION PATHOLOGY (GENERAL PATHOLOGY & HAEMATOLOGY) PAPER-I

A 20 year old male presented with swelling of both knees and pain for the past one week.    He gives history of similar episodes earlier.  He also gives history of excessive bleeding after minor injuries.  His maternal uncle has similar complaints and has been treated by repeated blood transfusions following excessive bleeding episodes.

1. What are the possible differential diagnoses?
2. What are the laboratory investigations required for the diagnosis?
3. What is the etiopathogenesis of theses disorders?
4. How will you make the final specific diagnosis?

2+4+3+1=10

WRITE SHORT NOTES ON:

5X4=20

Differences between benign and malignant tumors.

Bone marrow picture of megaloblastic anemia

Systemic thromboembolism

Leukemoid reaction

Morphologic changes in Kwashiorkor

WRITE BRIEFLY ON:

5X2=10

Name four types of necrosis with one example each

Name four clinical features of trisomy 21

Name four inherited cancer syndromes

Name four subtypes of Hodgkin disease

Give four examples of type II hypersensitivity