M.B.B.S. EXAMINATION BIOCHEMISTRY PAPER-I

Describe the process of β (beta) – oxidation of fatty acids.  Add a note on the energetics of the pathway.

7+3=10

A 6 year boy was taken to the hospital by his mother with complaints of decreased vision in the night.  The doctor suspected a possible vitamin A deficiency.  Describe in detail the sources, RDA, functions and deficiency manifestation of the deficient nutrient.  What other clinical features, the doctor has to look for in this case and what advice should be given?

1+1+3+3+2=10

WRITE SHORT NOTES ON:

5x4=20

Describe briefly the hormonal regulation of blood glucose levels.

Draw a plot of Competitive enzyme inhibition.  Give 2 examples of competitive inhibitors.

Briefly explain the following:

1. Specific Dynamic Action
2. Glycemic index

Describe the clinical significance of the following enzymes:

1.  LDH  ii)  Alkaline phosphatase  iii) Creatine kinase

iv)  Amylase   v)  Alanine transaminase

Give an outline of the electron transport chain including ATP generating sites

WRITE BRIEFLY ON:

5x2=10

Absolute specificity enzymes

Altered CNS behavior in patients with advanced liver disease.

Ethanol is administered in patients with methanol poisoning

Mention functions of  Hemoglobinopathies

Lactose intolerance